ODCs

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5 OMIM references -
5 associated genes
6 signs/symptoms

PROTEIN INTERACTIONS: 3

1 OMIM reference -
1 associated gene
8 signs/symptoms

Hereditary persistence of fetal hemoglobin - beta-thalassemia

Hereditary cerebral hemorrhage with amyloidosis, Dutch type


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	BCL11A HBG1 HBG2	(0.56) (0.56) (0.56)	APP APP APP

Citations in the biomedical literature:

Hereditary persistence of fetal hemoglobin - beta-thalassemia		Hereditary cerebral hemorrhage with amyloidosis, Dutch type
	Synonym(s): - HPFH - beta-thalassemia		Synonym(s): - HCHWA, Dutch type - HCHWA-D

	Classification (Orphanet): - Rare genetic disease - Rare hematologic disease		Classification (Orphanet): - Rare genetic disease - Rare neurologic disease - Rare systemic or rheumatologic disease

	Classification (ICD10): - Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism -		Classification (ICD10): (no data available)

	Epidemiological data: Class of prevalence: unknown Average age onset: childhood Average age of death: no data available Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: adulthood Average age of death: adult Type of inheritance: autosomal dominant

	External references: 5 OMIM references - No MeSH references		External references: 1 OMIM reference - 2 MeSH references: C537944 / D028243

Hereditary persistence of fetal hemoglobin - beta-thalassemia		Hereditary cerebral hemorrhage with amyloidosis, Dutch type
	Very frequent - Anaemia - Hemoglobinosis / hemoglobinopathy - Pallor - Splenomegaly Frequent - Anomalies of bones / skeletal anomalies - Hepatomegaly / liver enlargement (excluding storage disease)		Very frequent - Facial pain / cephalalgia / migraine - Intracranial / cerebral / meningeal hemorrhage - Psychic / behavioural troubles - Psychic / psychomotor regression / dementia / intellectual decline Frequent - Intracranial / cerebral calcifications - Seizures / epilepsy / absences / spasms / status epilepticus - Transient cerebral ischemia / stroke Occasional - Early death / lethality